In a placebo-controlled, double-blind, randomized trial, 26 adults with moderately elevated triglycerides (between 150-500 mg/dL) were given either 0.85 or 3.4 grams per day of the omega 3 fatty acids EPA and DHA for eight weeks.

The higher dosage lowered triglycerides by 27% compared to the placebo (173 ± 17.5 compared with 237 ± 17.5 mg/dL; P = 0.002).

No effect on triglycerides was seen at the lower dose. Neither dosage of omega 3 fatty acids had any effect on markers of inflammation or endothelial function. The findings were published in the February 2011 issue of the Journal of Clinical Nutrition.

For more information:
Skulas-Ray AC, Kris-Etherton PM, Harris WS, Vanden Heuvel JP, Wagner PR, West SG. Dose-response effects of omega-3 fatty acids on triglycerides, inflammation, and endothelial function in healthy persons with moderate hypertriglyceridemia. Am J Clin Nutr. 2011 Feb;93(2):243-52.
Skulas-Ray AC, West SG, Davidson MH, Kris-Etherton PM. Omega-3 fatty acid concentrates in the treatment of moderate hypertriglyceridemia. Expert Opin Pharmacother. 2008 May;9(7):1237-48

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Tags: HDL, LDL, LDL-C, T1DM, T2DM, diabetes, omega-3, triglycerides

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Diabetes Mellitus (DM) is a common metabolic disorder associated with abnormally high blood sugar levels. Diabetes is classified as either type 1 (T1DM), which is characterized by severely diminished insulin production, or type 2 (T2DM), which is characterized by moderately diminished insulin production in conjunction with insulin resistance (insensitivity of the tissues of the body to insulin). Insulin is a hormone that regulates blood glucose levels. Diabetes can seriously impair overall quality of life and may lead to multiple complications including heart disease, stroke, and kidney failure. According to the International Diabetes Federation, more than 245 million people have diabetes, with type 2 diabetes being the most prevalent.

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