In a placebo-controlled, double-blind, randomized trial, 26 adults with moderately elevated triglycerides (between 150-500 mg/dL) were given either 0.85 or 3.4 grams per day of the omega 3 fatty acids EPA and DHA for eight weeks.
The higher dosage lowered triglycerides by 27% compared to the placebo (173 ± 17.5 compared with 237 ± 17.5 mg/dL; P = 0.002).
No effect on triglycerides was seen at the lower dose. Neither dosage of omega 3 fatty acids had any effect on markers of inflammation or endothelial function. The findings were published in the February 2011 issue of the Journal of Clinical Nutrition.For more information:
Skulas-Ray AC, Kris-Etherton PM, Harris WS, Vanden Heuvel JP, Wagner PR, West SG. Dose-response effects of omega-3 fatty acids on triglycerides, inflammation, and endothelial function in healthy persons with moderate hypertriglyceridemia. Am J Clin Nutr. 2011 Feb;93(2):243-52.
Skulas-Ray AC, West SG, Davidson MH, Kris-Etherton PM. Omega-3 fatty acid concentrates in the treatment of moderate hypertriglyceridemia. Expert Opin Pharmacother. 2008 May;9(7):1237-48